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Moreover, nitrosylation, like phosphorylation, functions as a signaling pathway and plays a major role in regulating several physiological and pathological processes

Erastin upregulated the expression of lncRNA GABPB1-AS1, inhibited the translation of GABPB1 and the expression of the peroxidase gene, leading to the accumulation of ROS and MDA, and promoting tumor cell death, suggesting that GABPB1-AS1 may be the key to Erastin-induced ferroptosis [136, 137] (Table 2)

This includes the number and complexity of problems addressed, the amount and type of data reviewed, and the risk of complications or morbidity based on the treatment plan

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